Cardiovascular Risk Study
New Research Links Chronic Inflammation to a 43% Higher Cardiovascular Risk
Anonymous
Several reports emphasize that heart health in later life is shaped by risks and care addressed earlier: a decades-long study of nearly 2,700 Finnish men linked healthier midlife smoking, weight, blood pressure, cholesterol and blood-glucose measures with longer survival and better health in old age. World Heart Day guidance also urges routine screening and management of often silent conditions such as high blood pressure and diabetes, alongside regular exercise and a balanced diet, while another commentary highlights early recognition of heart-valve disease. New research involving nearly half a million UK adults associated higher chronic inflammation with changes in heart structure and a 43% higher risk of major cardiovascular events, including heart attacks and strokes. Separately, laboratory and animal research into doxorubicin-related heart injury identified a molecular pathway that may be interrupted by vorinostat, though the potential treatment requires further study before its relevance to patients is established.
Key Points
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The UK study used GlycA, a blood biomarker, to assess chronic low-grade inflammation, alongside heart imaging, genetic information and lifestyle factors.
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The researchers reported that people with higher inflammation markers had smaller heart chambers and thicker heart walls, changes associated with less blood being pumped with each heartbeat.
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The World Heart Day commentary says hypertension affects more than 30% of Jamaican adults and recommends a diet low in salt, sugar, fat and cholesterol, with vegetables, peas and beans, healthy fats and high-quality protein.
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In doxorubicin experiments, researchers found that topoisomerase IIβ increasingly attached to DNA regions where MEF2 was active, triggering unusually strong activity in MEF2-controlled genes. Vorinostat reduced this activity in laboratory experiments and reduced signs of heart injury in mice.
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